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heart-failure Clinical Trials

A listing of heart-failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 1,033 clinical trials
N Nicolas GIRERD, MD,PhD

Acute Heart Failure - COngestion Discharge Evaluation

Acute heart failure (AHF) is a major public health problem, associated with a 40% risk of death or re-hospitalisation at 3 months. This risk is significantly increased by insufficient decongestion at the end of hospitalisation for AHF assessed by a standardised clinical score, a natriuretic peptide dosage or by cardiac …

18 - 100 years of age Both Phase N/A

Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE)

The AHF-CORE study is a prospective, non-randomized, multicenter regional study. The main objective of the AHF-CORE study is to identify congestion markers (clinical, biological and ultrasound) at the beginning and at the end of hospitalization for acute heart failure that are more strongly associated with the risk of all cause …

18 - 100 years of age Both Phase N/A
A AUDE BOIGNARD

LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients

Heart failure is a severe disease affecting approximately 1-2% of the adult population in developed countries and around 26 million people worldwide. Up to 10% of these patients are in advanced stage heart failure, which is defined by a significant morbimortality and considerable medical expenses. Despite advances in its medical …

18 - 100 years of age Both Phase N/A
T Tarun Dasari

Low Level Tragus Stimulation in Acute Decompensated Heart Failure

Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation. Previous studies have demonstrated increased levels of cytokines such as C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10) and Tumor Necrosis Factor alpha (TNFα) in patients with heart failure …

18 - 80 years of age Both Phase N/A
N Nouran M Anwar

Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients

The goal of this clinical trial is to compare the effectiveness of acetazolamide versus dapagliflozin as an add-on in treating acute decompensated heart failure (ADHF) in adult patients with clinical signs of volume overload requiring intravenous loop diuretics. It will also assess the safety of these drugs when added to …

18 - 100 years of age Both Phase 3
F Fernando Esposito

Investigating ACute HeArt FailuRe Decongestion Guided by Lung UltraSonography

The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes. The main questions it aims to answer are: Does this strategy shorten the length of stay and reduce early hospital readmissions? Does …

18 - 100 years of age Both Phase N/A

Carmat Total Artificial Heart as a Bridge to Transplant in Patients With Advanced Heart Failure

The objective of this clinical investigation is to evaluate the efficacy and the safety of the Carmat Total Artificial Heart for the treatment of refractory advanced heart failure in transplant eligible patients.

18 - 100 years of age Both Phase N/A
N Nicolas GIRERD, MD,PhD

Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation

The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure. The main objective of the AHF-CODE preserved study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart …

18 - 100 years of age Both Phase N/A
J Jun Bo He

S086 Tablets for Chronic Heart Failure With Reduced Ejection Fraction

A randomized, double-blind, positive-drug parallel controlled, multicenter phase III trial of the efficacy and safety of S086 tablets in patients with chronic heart failure with reduced ejection fraction (HFrEF)

18 - 100 years of age Both Phase 3
N Nicolas GIRERD, MD,PhD

Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation

The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure. The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure …

18 - 100 years of age Both Phase N/A

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