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high-blood-pressure Clinical Trials

A listing of high-blood-pressure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 895 clinical trials
L Lukas Streese, PhD

Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.

This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and/or individualized exercise training intervention on blood pressure and vascular health. Furthermore the investigators want to decipher mechanisms, which contribute to vascular health by analyzing changes in metabolism and cell function in relation to vascular …

18 years of age All Phase N/A
D Danfeng Xu

Clinical Analysis of the Antihypertensive Effect of Laparoscopic Peripheral Nerve Blockade of the Renal Artery in Patients With Retroperitoneal Disease and Hypertension

The primary objective of this study is to evaluate the efficacy and safety of laparoscopic renal artery nerve blockade surgery in patients with retroperitoneal diseases complicated by hypertension. The study aims to address the following two questions: Can laparoscopic renal artery perivascular nerve blockade reduce postoperative blood pressure and decrease …

18 - 75 years of age All Phase N/A
C Catherine Bush, PhD, MPH

Low Energy Availability and Hypertension in Division I HBCU Athletes

Low energy availability (LEA) occurs when the body does not get enough calories to support both daily life and exercise. This can happen when athletes train hard but do not eat enough to match their energy needs. In both 2012 and 2023, the International Olympic Committee on Sports Nutrition recognized …

18 - 26 years of age All Phase N/A
S Sean Machak

Blood Pressure Following Isometric Exercise in Inactive Adults

This study investigates how isometric exercise training (IET) affects blood pressure in physically inactive adults. Isometric exercise involves sustained muscle contractions without movement-for example, pushing against a fixed object. Previous research has shown that IET may help reduce blood pressure, but the mechanisms involved are not fully understood. The purpose …

18 - 55 years of age All Phase N/A
L Liansy Valera

A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

The study will be a multi-center, randomized clinical trial to evaluate the safety and efficacy of using the Zona Plus handgrip therapy device compared to the use of an auditory relaxation therapy for treatment of high blood pressure and hypertension in subjects who are not currently taking antihypertensive medications. Half …

22 years of age All Phase N/A
D Darel Toh Wee Kiat, PhD

Sodium-rich COndiments Unifying Health and Taste

This research aims to develop an evidence-based classification for sodium-rich condiments (natremic index) based on their CVD-related risks. It is hypothesised that the acute cardiovascular and physiological response (effectively extrapolated to long-term CVD risks) to meals prepared with various sodium-rich condiments can be leveraged upon for the development of such …

50 - 75 years of age All Phase N/A
J Jun Cai

Effect of the Traditional Chinese Medicine Yufeng Ningxin in Patients With Hypertension

Yufeng Ningxin, a traditional Chinese medicine, has demonstrated potential antihypertensive effects in animal studies and small clinical trials, but has not yet been rigorously evaluated in large randomized clinical trials. Here, the investigators conducted a double-blind, randomized controlled trial to assess the efficacy and safety of Yufeng Ningxin tablets in …

18 - 65 years of age All Phase 4
P Paul Fitzgerald

Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

The diagnosis of hypertensive disease during pregnancy is predicated on strict blood pressure thresholds: 140/90 on at least two occasions measured four hours apart for both gestational hypertension and preeclampsia. An improvement in diagnostic accuracy of even 5mm Hg would be significant, as reflected by the US Association for the …

18 years of age Female Phase N/A

Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk

The goal of this clinical trial is to compare the short-term effects of three commonly prescribed antihypertensive drug classes (beta-blockers, ACE inhibitors, and calcium channel blockers) on postural balance and fall risk in adults with newly diagnosed primary hypertension. The main questions it aims to answer are: Do different antihypertensive …

18 - 75 years of age All Phase N/A
A Adam Gepner

Arterial Stiffness and Blood Pressure

Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and underlying individual genetic information. Older Veterans with hypertension are less likely to be treated to goal blood …

60 years of age All Phase N/A

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