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Found 60,240 clinical trials

Comparison of a Single Versus Double Perclose Technique for TAVR

Transcatheter aortic valve replacement (TAVR) has become widely recognized as a minimally invasive approach for aortic valve replacement in patients with severe aortic stenosis. It has been proven to be a safe and effective option for patients who are at low, intermediate, and prohibitive risk for surgical valve replacement. One …

65 - 100 years of age Both Phase N/A
C Cale T Queen, PhD

Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19

The primary objective of this study is to determine, in unblinded samples, whether artificial intelligence can classify specific blood RNA from patients with long COVID together and separately from apparently healthy normals and other medical conditions which share signs and symptoms of long COVID.

18 - 100 years of age Both Phase N/A

A Study to Evaluate Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets in Generalized Anxiety Disorder.

The study aims to evaluate the efficacy and safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets compared to placebo in adults participants with generalized anxiety disorder over a period of 8 weeks.

18 - 65 years of age Both Phase 3
H Hongguo Dai

GD-11 for Injection in the Treatment of Acute Ischemic Stroke

Phase III Clinical Trial of GD-11 for Injection in the Treatment of Acute Ischemic Stroke - A Multi-Center, Randomized, Double-Blind, Parallel, Placebo-Controlled Phase III Clinical Study with the primary objective of evaluation of the efficacy and safety of GD-11 for injection in the treatment of acute ischemic stroke patients within …

18 - 81 years of age Both Phase 3
W William G Shadel, PhD

The Impact of Standardized Tobacco Product Packaging on Young Adults in the Retail Environment

The overall aim of this research is to experimentally evaluate the extent to which partially standardizing the color of tobacco packaging influences tobacco use intentions among young adults who have varying levels of tobacco use experience.

21 - 29 years of age Both Phase N/A

Efficacy, Safety and Tolerability of KLU156 in Adults and Children ≥ 5 kg Body Weight With Uncomplicated P. Falciparum Malaria

This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination of ganaplacide (KAF156) and a solid dispersion formulation of lumefantrine (lumefantrine-SDF), when administered once daily for three days in adults and children ≥ 5 kg body weight and ≥ 2 months of age suffering …

2 - 100 years of age Both Phase 3

RESTORE - Phase II

The study will apply the principles of Community Based Participatory Research to evaluate implementation strategies, designed to assist in the delivery of an evidence-based lifestyle counseling intervention for pregnant participants. The primary strategies include a technology supported strategy (low touch) in which text messaging and online videos are used for …

18 - 89 years of age Female Phase N/A
H Haili Liu, Dr

ADC189 Tablets on Influenza A Virus Infection/Influenza B Virus Infection

The goal of this Phase II/III study is to investigate the safty and efficacy of ADC189 tablets in adolescents and adults with influenza A virus infection/influenza B virus infection. The main aim to answer: Phase II study is to evaluate the efficacy of ADC189 tablets in the treatment of adult …

12 - 65 years of age Both Phase 2/3
m mohamed G. Zeinhom, MD

Predictors of Post-alteplase Hemorrhagic Transformation of Brain Infarction

The investigators evaluated whether the characteristics of ischemic stroke patients, door-to-needle time, and stroke risk factors were predictive variables for different subtypes of post-alteplase hemorrhagic transformation of brain infarction.

18 - 75 years of age Both Phase 4
Y Yi Mo

Immunogenicity and Safety of Diphtheria, Tetanus, Pertussis (DTaP) Vaccine in 3-month-old Infants

The purpose of this study is to evaluate the safety and immunogenicity of the DTaP in 3-month-old infants.

3 - 3 years of age Both Phase 3

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