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Found 64,756 clinical trials
K Kendall Lewis

A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.

18 years of age All Phase 1/2

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific MTAP-deleted tumor types. The study drug, …

18 years of age All Phase 1/2
V Vicente Vanaclocha, MDPhD

Postoperative Scar in the Control Excess of Mobility Induced by Annulus Removal on Inserting a Lumbar Disc Prosthesis

To implant a complete lumbar disc prosthesis removal of the anterior portion of the annulus fibrosus is required. As the anterior portion of the annulus limits the movement in extension and axial rotation, we would like to know how much increase these two disc movements and also the effect on …

18 - 50 years of age All Phase N/A
M Michael L Thomas, PhD

Brain Stimulation Effects on Cognitive Task Performance

The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.

18 - 65 years of age All Phase N/A
X Xiaoyun Yang, Dr

The Clinical Efficacy of Immunomodulators in RA Patients

This study includes naive patients and csDMARDs-IR RA patients, treated with different regimens such as Iguratimod combination of different csDMARDs, or csDMARD with TNF inhibitors for 24 weeks. The disease activity and drug response will be observed. The immune disorder and synovial function will be evaluated at the same time.

18 - 80 years of age All Phase 4
R Ruescas-Nicolau A

Sedentarism of Stroke Survivors in the Valencian Community and Development of a Self-management Program

Stroke is the third leading cause of disability worldwide. Women present a higher incidence of this pathology and prevalence of its risk factors. Similarly, after stroke, women have a poorer functional outcome, higher rates of institutionalization and greater dependence on activities of daily living. People who have suffered a stroke …

18 - 90 years of age All Phase N/A
T Thomas N Eade, MBBS

Lu-PSMA for Oligometastatic Prostate Cancer Treated With STereotactic Ablative Radiotherapy

The aim of this study is to assess the progression free survival (PFS) of SABR alone and SABR + 177Lu-prostate-specific membrane antigen (PSMA) in patients with oligometastatic prostate cancer undergoing PSMA positron emission tomography (PET) staging.

18 years of age Male Phase 2

Development of Sleep Intervention for Parent and Child

This study aims to develop and test the intervention program to help manage parental thoughts in parents with child sleep problems.

6 - 24 years of age All Phase N/A

EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF

EACH-ADHF: Early Comprehensive Rehabilitation in patients with ADHF study is a multi-center, parallel-group, randomized controlled trial designed to evaluate the effects of the early comprehensive rehabilitation including exercise and inspiratory muscle training, over a period of 6 weeks, on the quality of life of patients with ADHF.

18 - 80 years of age All Phase N/A
M Marie-Christine ROUSSEAU, MD

Intensive Psychomotor Rehabilitation on Cognitive Motor Abilities and Adaptive Capacity on Children With Polyhandicap

Primary objective of the study is to compare and evaluate the impact of intensive care of rehabilitation of psychomotor vs. the standard care on adaptive behaviour of children with polyhandicap at 12 months after randomization.

4 - 13 years of age All Phase N/A

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