J Jai Shankar, MD

Management of CSDH With or Without EMMA- a Randomized Control Trial

EMMA-Can is an open-label randomized control trial comparing the recurrence risk in patients with chronic subdural hematoma (CSDH) undergoing standard of care treatment (surgical drainage and/or medical management) with or without embolization of the middle meningeal (EMMA).

J James Downar, MDCM, MSc

PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)

The goal of this multi-centre phase I/II open-label, single-arm study is to determine the safety, feasibility, therapeutic dose, and preliminary efficacy of psilocybin microdosing to treat psychological distress among patients with advanced illness. Forty patients will receive psilocybin drug product (1-3mg per day, Mon-Fri) for 4 weeks to be administered …

c christophe mariette, MD,PhD

Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma

The ADCI 002 trial is a large multicenter phase II-III prospective randomized controlled trial comparing primary surgery versus primary chemotherapy followed by surgery in patients with a resectable signet ring cell gastric adenocarcinoma

C Caroline Mitchell, MD, MPH

Vaginal Microbiota Transplant

This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis.

M Maria Muzik, MD, MSc

Postpartum Intervention for Mothers With Opioid Use Disorders

Opioid use disorder (OUD) is a fast-growing and devastating epidemic in the US with many mothers suffering cravings, depression, impaired interpersonal interactions and maladaptive parenting behaviors that may lead to child maltreatment and costly utilization of foster care. This interdisciplinary multisite project will begin with the high risk R61 phase, …

A Alison Moskowitz, MD

Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia

This phase II trial tests whether ruxolitinib works to shrink tumors in patients with T-cell large granular lymphocyte leukemia. Ruxolitinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Open and Endovascular Surgical Treatment for Artery Injuries

Traumatic injuries of peripheral arteries are often associated with multiple injuries, massive hemorrhage, state of shock, and loss of blood supply, as well as with high mortality. Traditionally, an open surgical approach is suggested for the management of artery injury. With the advancement of endovascular techniques, the traditional open vascular …

K Kim Geok Soh

Effects of High-Intensity Interval Training on Physical Fitness, Skills, and Tactical Performance, 12 Weeks High-Intensity Interval Training

This clinical trial aims to compare the difference between high-intensity interval training and common traditional training on physical fitness, skills, and tactical performance among college ice hockey players in China. The main questions it aims to answer are: 1. How does high-intensity interval training affect the physical fitness of college …

S Shao Hua Ko

Comparison of Rigid and Non-Rigid Interbody Fusion Device for Cervical Degenerative Disc Disease in Adults

Rigid interbody fusion device in bulk configuration has been widely used in anterior cervical discectomy and fusion (ACDF) surgery. It is a randomized, prospective, multicenter clinical study to compare rigid and non-rigid fusion device in ACDF for cervical degenerative disc disease.

E Evelien Vandeurzen, MsC

Surveying the Receptivity for Telemedicine Pre-operative Consultation in UZ Brussel.

We will be surveying patients coming to UZ Brussels for their pre-operative consultation, how they feel about changing these consultations to teleconsultations.