Rochester, Minnesota Clinical Trials

High Resolution Gastric Mapping and Gastroduodenal Manometry

Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation. Therapeutic options manage symptoms, and there is no FDA approved medical therapy for dyspepsia. There is a need for better objective understanding of sensorimotor …

C Clinical Trial Referral Office

Schedule De-Escalation of 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

This phase II trial studies how to improve the usage of Lu 177 vipivotide tetraxetan (177Lu-prostate-specific membrane antigen \[PSMA\]-617) for treating patients with castration-resistant prostate cancer that has spread from where it first started (primary site), to other places in the body (metastatic) utilizing a treatment pause after 5 cycles …

K Kelly J Feuerhak

Understanding Mechanisms of Normal and Disordered Defecation

Researchers are trying to better understand why constipation occurs and improve the tests for diagnosing these conditions.

C Christin Tiegs-Heiden, MD

Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas

Osteoid osteomas are painful, benign bone tumors that occur most frequently in young males between ages 10 and 20 years. The goal of the proposed study is based on the premise that MRgFUS is noninferior to CT-guided radiofrequency ablation (CTgRFA), in terms of pain reduction following treatment of osteoid osteomas, …

V Virend Somers, MD, Ph.D

Beetroot Juice and Sleep

The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.

E Eva Morava-Kozicz, MD, PhD

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.

C Cassie L Zell, MA

Health and Wellness Coaching to Improve Thoracic Transplant Caregiver Self-Efficacy

This is a pilot study examining the effects of telephonic health and wellness coaching on self-efficacy and caregiving burden for caregivers of patients awaiting heart or lung transplant.

S Scott Bainbridge, MD

Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

A Randomized, Double-Blind, Placebo-Controlled, Single Dose Study to Assess the Safety and Efficacy of SL1002 for the Treatment of Knee Pain in Patients with Osteoarthritis of the Knee.

K Kelly J Feuerhak

Management of Dyssynergic Defecation

The purpose of this research is to better understand constipation and improve biofeedback treatments.

C Clinical Trial Referral Office

Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial

This clinical trial evaluates the effect of radiotherapy doses based on tumor size and tumor-specific characteristics (biologically-adapted) in treating patients with Ewing sarcoma. Radiotherapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Conventional radiotherapy uses minimal imaging support to determine the positioning of …