Takoma Park, Maryland Clinical Trials

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Environmental Risk Factors for the Anti-synthetase Syndrome

Background Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors. Some researchers believe that people who are susceptible to autoimmune disorders develop them when the body reacts to environmental or other factors by creating white blood cells that attack the body s …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

The Mechanistic Biology of Primary Immunodeficiency Disorders

Background Primary immunodeficiency disorders, or PIDs, are diseases that weaken the immune system. This makes it easier for a person to get sick. Some PIDs are mild and may not be diagnosed until later in life. Other kinds are severe and can be identified shortly after birth. Researchers want to …

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Characterization and Treatment of Adolescent Depression

This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Natural History of Familial Carcinoid Tumor

This study will evaluate members in families with a history of small bowel carcinoid cancer to study the natural history of those family members that have the disease, determine ways to improve early detection by performing surveillance on those at risk but without disease and to identify the gene(s) that …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation. This may include inherited conditions, such as X-linked severe combined immunodeficiency (XSCID), chronic granulomatous disease (CGD), and leukocyte adhesion deficiency (LAD), or conditions resulting from outside factors, such as graft-versus-host disease …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Phenotype/Genotype Correlations in Movement Disorders

The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients …

V Vijay Ramchandani, Ph.D.

COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

Background The SARS-CoV-2 virus has caused a pandemic infection called COVID-19. It is a global threat to people, communities, and health systems. Researchers are concerned about the mental health effects of the pandemic. They want to learn more about how it is affecting people s alcohol use and problems, and …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures. In addition to studying the natural history of untreated patients, the natural history of patients receiving approved disease-modifying therapies of MS will be examined. In both cohorts of patients levels …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Study of Premenstrual Syndrome and Premenstrual Dysphoria

The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS). Women who experience PMS symptoms will complete clinical interviews, self-rating scales, and evaluations of mood and endocrine function. A subgroup of women with severe PMS (Premenstrual Dysphoric Disorder or PMDD) will be offered additional …