Takoma Park, Maryland Clinical Trials

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Background Primary sclerosing cholangitis is a rare chronic liver disease. It affects the bile ducts of the liver. It can result in bile duct infections, cirrhosis, cancer, and end stage liver disease. Researchers want to learn more about this disease. Objective To understand the biological causes of primary sclerosing cholangitis. …

S Susan Conway, MD

T Cell Therapy Opposing Novel COVID-19 Infection in Immunocompromised Patients

This is an open label, phase I dose-escalation study to evaluate the safety of coronavirus-specific T cell (CST) therapy for prevention of SARS-CoV-2 infection in immunocompromised patients following hematopoietic stem cell transplantation (HSCT). Participants will receive donor-derived CSTs for prevention of SARS-CoV-2 infection after HSCT (≥28 days and \<4 months …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Deep Brain Stimulation Surgery for Movement Disorders

Background \- Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments. DBS uses a battery-powered device called a neurostimulator (like a pacemaker) that is placed under the skin in the chest. It is used to stimulate …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Men at High Genetic Risk for Prostate Cancer

Background Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Tumor Related Epilepsy

Background Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tumors. It may completely …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

Background Certain blood cancers can be treated with blood or bone marrow transplants. Sometimes the donor cells attack the recipient's body, called graft-versus-host disease (GVHD). The chemotherapy drug cyclophosphamide helps reduce the risk and severity of GVHD. Researchers want to learn if using a lower dose of cyclophosphamide may reduce …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Data Collection of Standard Care of Patients in the EMG Section

Background Most people who are referred to the EMG (Electromyography) Section of the NIH are enrolled into specific active studies. This allows researchers to learn about a range of rare neuromuscular disorders. But study criteria may not give researchers the chance to evaluate a single person or study a common …

Natural History of KSHV-Associated Multicentric Castleman s Disease

Background Kaposi s sarcoma herpes virus (KSHV) causes several kinds of cancer, Kaposi sarcoma (KS), a form of Multicentric Castleman s Disease (MCD) and a type of lymphoma known as Primary Effusion Lymphoma (PEL). These cancers can occur alone or at the same time in the same patient. MCD can …

Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis

Background \- Lymphangioleiomyomatosis (LAM) is a rare type of lung disease that occurs almost exclusively in women. In LAM, muscle tissue grows in the lungs and starts to block the flow of air. It is a progressive disease, and in severe cases may require a lung transplant. One possible treatment …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea

Background Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep. Pediatric OSA can be especially concerning and can have long-term effects. Researchers want to see how a monitoring device called near-infrared …