Hyattsville, Maryland Clinical Trials

Post-Concussion Musculoskeletal Injury Risks

Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19 years and account for 22% of all combat casualties. Concussion, a mild form of TBI, increases …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Background Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders. To do this, they need to collect biological samples from people with blood disorders. They also need to collect samples from healthy people. Objective To collect samples …

Study of Chediak-Higashi Syndrome

Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized in its classical form by oculocutaneous albinism, a bleeding diathesis, recurrent infection due to abnormal neutrophil and natural killer cell function, and eventual progression to a lymphohistiocytic infiltration known as the accelerated phase . Death often occurs within the first …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Investigational Use of Neuromuscular Ultrasound

Background Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Researchers are looking for ways to improve the ability to observe nerves and muscles and how they function in this natural history protocol. Objective To …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Surgery as a Treatment for Medically Intractable Epilepsy

Background Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures completely or almost completely in one-half to two-thirds of patients who qualify for surgery. The tests and …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Natural History of Noncirrhotic Portal Hypertension

Background Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. It seems to start slowly and not have many warning signs. Many people may not even know that they have a liver disease. There are no specific treatments for NCPH. …

F Farinaz Safavi, MD

Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity

Background Immune system and nervous system have significant interaction so that People with immunity diseases can have complications that affect the nervous system and people with some neurological disease may have defects in their immune system.These complications can affect many body functions, including how they move, walk, think, and feel. …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

Background Bruton s tyrosine kinase inhibitors (BTKi) are used to treat a form of leukemia. But taking BTKi can also increase a person s risk of developing an abnormal heart rhythm. This can cause sudden death. In this natural history study, researchers want to learn how BTKi affects the heart. …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

The Metabolism, Infection and Immunity (MINI) Study is a longitudinal natural history study at the National Institutes of Health (NIH) that aims to define the relationship between infection, immunity and clinical decline in individuals with mitochondrial disease. Mitochondrial diseases are a group of disorders caused by problems with the cell …

S Sarfaraz Hasni, M.D.

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

Background Systemic lupus erythematosus (SLE) is a disease that affects females nine times more often than males. People with SLE are often treated with cyclophosphamide (CYC). But CYC can damage a woman s ovaries; it may cause infertility. A drug called GnRHa is sometimes given to protect the ovaries during …