Montreal, Quebec Clinical Trials

M Meaghan Preston

Radiation OmisSion in PAtients With CLinically Node Negative Breast Cancer Undergoing Lumpectomy

To de-escalate radiation therapy in women with breast cancer.

L Louis-Philippe Fortier, MD

Comparison of Neuromuscular Recovery at the Hand and Foot

Gold standard for neuromuscular blockade evaluation is accelerometry in three dimensions at the thumb. There are many times that measurement at the hand can be falsely under-estimated intraoperatively secondary to constriction of the upper extremities. We believe that installing the same accelerometer at the first toe will give us similar …

G Gabriel Altit, MD

NIRS in Congenital Heart Defects - Correlation With Echocardiography

Neonatal patients with congenital heart defects (CHD) have changing physiology in the context of transitional period. Patients with CHD are at risk of low perfusion status or abnormal pulmonary blood flow. Near infrared spectroscopy has been used in neonatal intensive care units (NICU) to measure end-organ perfusion. The investigator plan …

E Emmanuel Olarewaju, PhD Candidate

HYEEG Discourse in Psychosis: A Neurobehavioural Study

This multimodal study explores the mechanisms underlying social dysfunction in individuals with schizophrenia. It focuses on the relationship between disorganized communication and social interaction, aiming to identify measurable markers of disorganized communication and link them to clinical symptoms and social functioning. Key Research Questions: How do neural and behavioural synchrony …

S Sharon L Shapiro, BScN

Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients

Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle muscles. However, despite its clinical relevance, the natural development of spasticity over the first 3 months …

Sperm Oxidative Stress and Pregnancy Success During IUI and IVF

Oxidative stress (OS) is characterized by an imbalance between the production of reactive oxygen species (ROS) and the ability of the body to eliminate them. Such an imbalance can lead to lipid peroxidation, DNA damage and cell apoptosis. Studies have suggested that infertile men are more likely to have high …

G Gabriel Altit, Co-Site Lead

Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)

Bronchopulmonary dysplasia (BPD) is a common, major complication of premature birth, associated with developmental and health consequences that continue into adulthood. Prediction of who will have these problems is challenging using traditional definitions of disease. It is believed that underdevelopment and injury occur in both lung tissue and the blood …

G Gabriel Altit, MD

Postnatal Steroids Effects on Cardiac Function in Extremely Preterm

Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects before and after dexamethasone administration on cardiac structure/performance will be evaluated by using the M-mode technique (Devereux …

G Gabriel Altit, MD

Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia

CDH is associated with lung hypoplasia, pulmonary hypertension, and left ventricular hypoplasia. Use of new STE techniques (heart ultrasound) showed that CDH newborns have decreased LV size and function, potentially explaining the non-response to iNO, and that these cardiac findings were associated with poor outcomes. Our hypothesis: CDH newborns persist …

G Gabriel Altit, MD

Pulmonary Vascular Disease and Cardiac Performance in Extreme Preterm Infants

Pulmonary vascular disease and cardiac performance in extreme preterm infants: A prospective cross-sectional study