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Herdecke, Germany Clinical Trials

A listing of Herdecke, Germany clinical trials actively recruiting patients volunteers.

Found 113 clinical trials

Efficacy and Safety of Carfilzomib in Combination With Ibrutinib vs Ibrutinib in Waldenström's Macroglobulinemia

In Waldenström macroglobulinemia (WM) chemotherapy induces only low CR/VGPR (Complete Remission/ Very Good Partial Response) rates and responses of short duration compared to other indolent lymphomas. Thus, innovative approaches are needed which combine excellent activity and tolerability in WM. Chemotherapy-free approaches are highly attractive for this patient group. Based on …

18 - 100 years of age Both Phase 2

PLATON - Platform for Analyzing Targetable Tumor Mutations (Pilot-study)

PLATON (Platform for Analyzing Targetable Mutations) is a prospective, multicentre, observational cohort study with biobanking. In a first approach PLATON's pilot-study assesses genomic profiling in gastrointestinal cancer therapy and the frequencies of targetable mutations including Tumor Mutational Burden (TMB) and Microsatellite Instability Status (MSI), performing Next-generation deep sequencing (NGS) using …

18 - 100 years of age Both Phase N/A
B Bernhard Ludvik, Prof. MD

Combined Active Treatment in Type 2 Diabetes With NASH

The aim of this multicentre, prospective, placebo-controlled, double-blind, randomized, 3-arm parallel group, interventional study is to assess for the first time the effects of either a combined therapy with the antihyperglycemic drugs semaglutide and empagliflozin or empagliflozin monotherapy compared to placebo as potential treatments for non-alcoholic steatohepatitis (NASH) in patients …

25 - 75 years of age Both Phase 4
Z Ziad Hilal, M.D.

Coughing at Time of Cervical Biopsy

To investigate the effect of coughing as an intervention to reduce pain in colposcopy guided biopsy.

18 - 80 years of age Female Phase N/A
D Dominik Schneider

Music Therapy With Cancer Affected Children and Their Families

Background: Pediatric oncology patients and their families are in an existentially threatening situation for which music therapy has proven as a cross-linguistic field of action: the creative act of making music offers the possibility of strengthening individual competences and makes socio-psycho-biological conflicts tangible in a very direct way. Although music …

5 - 13 years of age Both Phase N/A

Effectiveness of Radial Extracorporeal Shockwave Therapy in Patients With Chronic Low Back Pain

Analysis of the effectiveness of radial shock wave therapy as part of a multimodal pain therapy in the inpatient setting. Different therapy protocols are compared in previously non-operated and in previously operated patients.

18 - 80 years of age Both Phase N/A

Plasma On Chronic Wounds for Epidermal Regeneration

Every year, 5 million people throughout Germany suffer from extensive, often chronic wounds. Cold plasma is an innovative therapeutic approach in the treatment of these persistent tissue defects. However, previous therapy options with cold plasma are very time-consuming, especially with increasing wound area, and are also strongly dependent on the …

18 - 100 years of age Both Phase N/A
O Omid Madadi-Sanjani, Dr.

Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds ("MUC-FIRE" Trial)

The primary objective of this study is to demonstrate that mucous fistula refeeding between enterostomy creation and enterostomy closure reduces the time to full enteral feeds after enterostomy closure compared to standard of care.

- 12 years of age Both Phase N/A
S Stjepana Kovac, PD Dr.

Trial to Evaluate Efficacy and Safety of Bortezomib in Patients With Severe Autoimmune Encephalitis

Autoimmune Encephalitis is a disorder of the central nervous system caused by bodily substances, called antibodies. Antibodies normally help the body to prevent infections. However, in this disorder, the antibodies turn against the body itself and especially against cells in the brain and disturb the normal brain function. They are …

18 - 100 years of age Both Phase 2

BRAF Inhibitor Encorafenib And Cetuximab Real Life Investigation of Next Generation CRC Treatment

The presence of a BRAFV600E mutation is a marker of poor prognosis in patients with mCRC and associated with a median overall survival (mOS) of approximately 12 to 14 months compared to 20 to 25 months for patients with BRAF wild-type tumours. After 1st line therapy, treatment outcomes with standard …

18 - 100 years of age Both Phase N/A

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