Biejing, China Clinical Trials

L Li Huo, MD

PET Imaging of Fibroblast Activation in Atherosclerosis

Fibroblast activation protein (FAP) is a fibroblast-specific marker expressed in atherosclerosis, associated with endothelial-to-mesenchymal transition and a rupture-prone plaque phenotype. This study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with FAPI PET and its correlation with histological vulnerability and clinical outcome.

Z Zhaohui Tong, Dr

Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration

Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the best treatment strategy has not been determined. Based on this, this project intends to take patients with severe community-acquired pneumonia …

L Lulu Ma, MD

Anesthesia Neurodevelopmental Impact in Congenital Scoliosis Children

In the past, a large number of animal studies have suggested that anesthesia exposure has potential neurotoxic effects, resulting in persistent cognitive and behavioral deficits. At present, there is still a lack of sufficient clinical research evidence to prove whether anesthesia exposure has long-term effects on neurodevelopment. The existing clinical …

A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD

This is a Prospective, Non-interventional, Multicenter, Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients with Neovascular (Wet) Age-related Macular Degeneration (nAMD). All subject who completed the parent clinical study (NCT06213038 and NCT05986864) will undergo safety and efficacy assessments up to 5 years post study drug injection.

The Optimal Number of Fiducial Marker for Stereotactic Body Radiotherapy

This is a clinical study focused on the use of fiducial marker-guided stereotactic body radiotherapy (SBRT) for treating malignant tumors, including lung, liver, pancreatic, and kidney/adrenal cancers. Here's a breakdown of the key components of the study: Study Design: Prospective, single-center, exploratory clinical study. Patient Enrollment: The study intends to …

C Chaowu Yan, PhD and MD

Cerebral Microembolization Associated With PFO Closure

This study aims to investigate (1) the de novo cerebral microembolization in patients who undergo transcatheter closure of PFO or ASD, and (2) evaluate the relationship between de novo cerebral microembolization and in situ thrombus within PFO.

F Fa Lin, MD

Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)

Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids. Neurosurgery is the only department that can open the skull. In addition to blood and cerebrospinal …

G Guoyi Gao, MD

Correlation Patterns of Brain Temperature-Pressure in Acute Brain Injury

The goal of this prospective, multicenter, observational, cohort trail is to explore the pattern of brain temperature-brain pressure association in acute brain injury and to clarify its predictive value for prognosis and neurological function 30 days after acute brain injury.

W Wang Yan, M.D.Ph.D.

Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section

Identify the risk factors for Placenta accreta spectrum (PAS) disorders in women without prior caesarean section (CS). Clarify the prognostic factors of the disease and explore individualized treatment options to improve the prognosis of patients with this type of disease; Use the cohort's biological sample database to conduct serology, cytology, …

J Jinhao Lyu, MD

Thrombus Imaging and Treatment Analytics in Neurology

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.