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metabolic-disorders Clinical Trials

A listing of metabolic-disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 2,562 clinical trials
G Garry Shen, MD PhD

Saskatoon Berry on Metabolism and Gut Microbiota in Healthy Subjects

Diabetes becomes epidemic in worldwide countries. Nine out of ten diabetic patients are type 2 diabetes (T2D). T2D is characterized by insulin resistance and obesity. Uncontrolled diabetes leads to serious consequences including heart attack, stroke, chronic renal failure, liver failure, blindness and low limb amputation. Most of hypoglycemic medications have …

18 - 75 years of age Both Phase N/A
L Leanne Hodson

Blood Lipid Responses to Diet

The macronutrient composition of our diet (proportions of carbohydrates, fats and proteins) strongly influences the way our body stores and utilises substrates (e.g., fats and sugars), which in turn influences our risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the …

18 - 65 years of age Both Phase N/A
J Johannes Häberle, Prof Dr

Ureagenesis Analysis in Healthy Subjects and in Urea Cycle Disorder Patients

Urea cycle disorders (UCDs) are dramatic congenital inherited metabolic disorders. There is no cure. Many novel therapeutic approaches are currently being developed, which hopefully will change the current situation. Testing the efficacy of such new therapies in patients is a challenge, because many clinical parameters are influenced by several disturbances …

- 100 years of age Both Phase N/A
T Tanya Reinfeld, RN

A Pilot Program Measuring Effectiveness of Health Coaching Interventions

Women will participate in a workshop within a group and individual meetings. the workshop will include providing information regarding guidelines for healthy eating, engaging in physical activity, personal training tools to build self-efficacy and to encourage implementing a healthy life style.

18 - 100 years of age Female Phase N/A
R Robert Vangel, BSc

Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones

Small exploratory open-label pilot study to assess supplementation of a ketone ester (Juvenescence) combined with a 'ketogenic-mimicking diet' as a potential therapy for persons with bipolar disorder.

18 - 100 years of age Both Phase N/A
E Eva-Maria Ratai, PhD

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide …

18 - 45 years of age Both Phase N/A
J Jens-Christian Holm, Ass. Prof, PhD

The Danish Childhood Obesity Biobank

The Danish Childhood Obesity Biobank aims to produce a scientific platform for research in obesity: Bio-clinical data are collected from two cohorts - an obesity clinic cohort and a population-based cohort. The biobank thus facilitates translation between research and clinical practice of obesity treatment and related complications.

2 - 100 years of age Both Phase N/A
F Fatima Tensun

A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes

The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous beta cell function and influence glycemic parameters in adolescent and adults recently diagnosed with T1D carrying the HLA …

12 - 28 years of age Both Phase 3

Blood Spot and Urine Metabolomic Screening Applied to Rare Diseases

The primary goal of this study is to establish a biobank of dried blood spots and urines from a large control cohort and collect several cohorts as large as possible of patient affected or suspected of being affected by rare diseases (mainly hereditary metabolic diseases) or by autism spectrum disorders. …

1 - 99 years of age Both Phase N/A
G Ger Koek, MD, PhD

NAFLD Primary Care

Non-alcoholic fatty liver disease (NAFLD) is with 25% the most prevalent liver disorder in Western society and is associated with overweight, obesity, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD) and increased risk of cancer development. NAFLD is defined by a hepatic fat accumulation of more than …

18 - 80 years of age Both Phase N/A

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