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Connective Tissue Diseases Clinical Trials

A listing of Connective Tissue Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 370 clinical trials
C Chrisanna Dobrowolski, MD

Alnuctamab for Refractory SLE (LATTE Study)

This study will assess the safety and preliminary efficacy of the bi-specific TCE, alnuctamab (known as BMS-986349, CC-93269, EM901), targeting BCMA in patients with moderate to severe SLE, refractory to standard-of-care treatments.

18 - 60 years of age All Phase 1
M Mengtao Li, Doctor

The Purpose of This Study is to Evaluate the Efficacy and Safety of 626 in the Treatment of SLE

This study will evaluate the effect and safety of 626 in patients with SLE

18 - 70 years of age All Phase 1/2
X Xue He

Study of Ultra-Fast CD19 CAR-T Therapy for Refractory SLE

This is an investigator-initiated trial aimed at assessing the safety and efficacy of ultra-fast autologous CD19-targeted CAR-T cells in the treatment of refractory systemic lupus erythematosus.

5 years of age All Phase 1
Q Qiubai Li, Professor

A Clinical Study Exploring the Safety, Efficacy and Cell Metabolic Dynamics of Universal CD19 / 20 Car-t Cell Injection in Moderate to Severe Refractory Systemic Lupus Erythematosus

This study is a single arm, open, exploratory dose escalation clinical study to evaluate the safety, efficacy, and cellular metabolic dynamics of ct1195e cells in patients with SLE.

18 - 65 years of age All Phase 0

Study of YK012 in Moderate to Severe Systemic Lupus Erythematosus

The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of YK012 in participants with Moderate to Severe Systemic Lupus Erythematosus (SLE).

18 - 75 years of age All Phase 1/2
E Ebtehal Alaa El-Din Kotop Mohamed, Lecturer

" TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by diverse clinical manifestations, prominently involving the skin.

18 - 60 years of age All Phase N/A
X Xiaodong Zhao, PhD

Study of CD19 CAR-T Therapy for Refractory SLE

This is an investigator-initiated trial aimed at assessing the safety and efficacy of PTOC1 cells Injection in the treatment of refractory systemic lupus erythematosus.

5 years of age All Phase 1
Y Yuqi Zhang

Early Myocardial Dysfunction Helps Identify Severe Refractory Pediatric Lupus

To investigate biomarkers to identify pediatric SR-SLE patients by non-invasive echocardiographic techniques.

7 - 17 years of age All Phase N/A
F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM)

Dermatomyositis (DM) is a rare autoimmune disease that causes muscle weakness, skin rashes, and other symptoms. Researchers think both genetic and environmental factors play a role in this disease. They want to find out more about how diet and lifestyle choices affect people with DM/JDM. Objective To see if omega-3 …

18 - 60 years of age All Phase 2
l lei liu

A Phase I Study to Assess LBL-047 in Healthy Adults and Patients With Systemic Lupus Erythematosus

A Phase I, Double-Blind, Randomized, Placebo-Controlled, Dose-Escalation Study of Single Subcutaneous Injections of LBL-047 in Healthy Adults and Patients with systemic lupus erythematosus.

18 - 60 years of age All Phase 1

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