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mitral-valve-regurgitation Clinical Trials

A listing of mitral-valve-regurgitation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 214 clinical trials
S Suson (Sue) Walsh

MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics

The Researchers are trying to test a MR imaging method for detection of Cerebral Spinal Fluid (CSF) flow in the brain to help diagnosis and better understand diseases that affect brain function.

18 years of age All Phase N/A
T Timothy J Henrich, MD

Pharmacokinetics Distribution of Raltegravir by PET/MR

This is a single-center drug distribution and pharmacokinetic study of a single microdose of 18F-raltegravir given to 10 HIV-infected subjects who are either taking or not taking a raltegravir-containing ART regimen. After administration of IV 18F-raltegravir, subjects will undergo PET/MRI in order to determine the distribution of radiolabeled drug through …

18 years of age All Phase N/A
R Roselove Asare, MA

Hyperpolarized Xenon-129 MR Imaging of the Lung

Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked …

18 years of age All Phase 1/2
T Timothy J Henrich, MD

Imaging Immune Activation in HIV by PET-MR

This is a single center exploratory imaging study involving one intravenous microdose of [18F]F-AraG followed by whole-body positron emission tomography-magnetic resonance (PET-MR) imaging in HIV infected individuals to determine the anatomical distribution of the PET tracer. Participants will be enrolled if they were treated during early or late HIV infection. …

18 years of age All Phase 1
A Arndt-Christian Müller

Study of MR-based IGRT for Prostate Cancer

MR (Magnetic Resonance Imaging) - based IGRT (image-guided radiotherapy) for patients with prostate carcinoma.

18 years of age Male Phase N/A
R Raymond Mak, MD

Jump: MR Simulation For Radiation Therapy Master Protocol

This is a master protocol for a prospective Phase I-II study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatments.

18 years of age All Phase N/A

Imaging Neural Correlates of Ketamine Using PET/MR

The purpose of this randomized, placebo-controlled study is to investigate pharmacodynamic differences between racemic ketamine and esketamine using functional fluorodeoxyglucose ([18F]FDG) positron emission tomography/magnetic resonance imaging (PET/MR) Pilot study I: A pilot study with healthy controls will be performed in order to investigate pharmacokinetic behavior and acute behavioral effects of …

18 - 55 years of age All Phase 1
H Hannah Howlett

USPIO Enhanced MR Imaging in CNS Tumours (UMIC)

The immune response or inflammation is known to be a key driver of progression and growth in many solid tumours. Inflammatory cells called macrophages are present in high numbers in many brain tumours and these tumour associated macrophages or TAM are thought to have prognosis and treatment implications in these …

16 - 100 years of age All Phase N/A
N Nian-Zeng Xing, M.D.

MR-linac Guided Ultra-hypofractionated RT for Prostate Cancer

To investigate the tolerability of MR-linac based stereotactic ablative radiotherapy (MRL-SBRT)for patients with localized prostate cancer To assess the acute and late toxicities, efficacy and quality of life for patients treated by MRL-SBRT To simulate the dose planning and assess the feasibility of simultaneous-boost for MR-prominent foci To investigate the …

18 years of age Male Phase N/A
M Megan Schmitt

Use of Hyperpolarized 129Xe MR Lung Imaging in Infants

Abnormalities of the lungs are common in newborns and can include aspiration or infectious pneumonia, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), congenital diaphragmatic hernia (CDH), and other abnormalities of lung development. Diagnostic radiography is commonly used in this population to differentiate diagnosis and to assess changes …

- 6 years of age All Phase 4

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