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headaches Clinical Trials

A listing of headaches medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 229 clinical trials
A Alex Carrizales

Multisite Advancement of Research on Chronic Posttraumatic Headache

Posttraumatic headache (PTH) is a common and highly disabling consequence of traumatic brain injury (TBI) in U.S. military service members and veterans. Cognitive Behavioral Therapy for PTH has been shown to significantly improve disability outcomes in veterans with persistent PTH when delivered in-person. Telemedicine platforms can dramatically increase access to …

18 - 70 years of age Both Phase N/A
A Alessandro Di Martino, MD

PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT

The aim of the study is to compare the 12-month clinical outcomes of patients with patellofemoral osteoarthritis undergoing infiltrative treatment with fresh PRP and HA

30 - 65 years of age Both Phase N/A
K Karen Ahern, BSN MBA

Magnesium and Riboflavin Treatment for Post-Concussion Headache

This clinical trial will try to determine if the supplements magnesium and riboflavin will reduce the pain and duration of headaches in persons diagnosed with a concussion. The participant will be randomized to either active magnesium and riboflavin capsules or placebo (inert) capsules. The capsules will be taken once a …

18 - 40 years of age Both Phase 2
K Kawal P Singh

Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches

Chronic daily headaches (CDH) poses a significant burden on patients, healthcare systems and the society. Intravenous (IV) ketamine infusion, an intervention that is widely available and scalable, can treat CDH by reversing receptor-mediated sensitization. This study is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers …

18 - 100 years of age Both Phase 3

Evaluation of the Single Injection of BMAC vs HA in the Treatment of the Ankle Osteoarthritis

The aim of the study is to compare the efficacy of the infiltrative therapy of BMAC vs HA up to 24 months in the treatment of the ankle osteoarthritis. The efficacy will be assessed through clinical, objective and subjective evaluations. After 12 months patients in the control group can decide …

18 - 70 years of age Both Phase N/A
E Emmanuelle Schindler, MD, PhD

Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1

The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.

18 - 100 years of age Both Phase 1
J Jay-Jinguang Zhu, MD

A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients

The purpose of this study is to o determine whether the modified LP procedure reduces the incidence of PLPH to 5% or lower, to determine whether the modified LP procedure reduces the frequency of epidural blood patch (EBP) usage to 10% or lower of the PLPH population and to identify …

18 - 100 years of age Both Phase N/A
K Katherine Ross, PhD

Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH

This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify methods of preventing post-traumatic headache persistence. The objective of the clinical trial component of the Focused Program is …

18 - 70 years of age Both Phase 2
H Hong-Wei Dai

Xuefu-Zhuyu Capsule for the Treatment of "Qizhi Xueyu Zheng" (Qi Stagnation and Blood Stasis Syndrome)

"Xuefu-Zhuyu capsule" (XFZY) is made from a classic Fangji "Xuefu-Zhuyu Decoction" in an ancient Chinese medical book "Yi Lin Gai Cuo" by Chinese physician Wang Qingren, which is the most representative formula for the treatment of "Qizhi-Xueyu Zheng" (Qi Stagnation and Blood Stasis Syndrome). XFZY concludes 11 kinds of Chinese …

18 - 75 years of age Both Phase 4
E Erling Tronvik, md phd

Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache

Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory. An important nerve pathway involved in the pain attacks has a switching station at the sphenopalatine ganglion (SPG) located in …

18 - 85 years of age Both Phase 3

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