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knee-replacement Clinical Trials

A listing of knee-replacement medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 205 clinical trials

ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population

Five-year, Prospective, multi-center, non-randomized, non-controlled study of the ATTUNE® Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing (PS) femoral component in complex primary total knee arthroplasty.

22 - 80 years of age Both Phase N/A

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

Supracondylar femur periprosthetic fractures about a total knee arthroplasty (TKA) are a catastrophic and challenging complication of TKA and unfortunately are increasing in incidence. Fixation of these fractures can be challenging due to altered anatomy for the TKA and the presence of the metallic femoral component and have a relatively …

55 - 100 years of age Both Phase N/A
C Cecilie D Skov, MD

Motivational Feedback Following Total or Unicompartmental Knee Arthroplasty

The goal of this randomized controlled trial (RCT) nested in a prospective cohort study is to investigate whether physical activity (PA) following total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) can be optimized by the use of an activity tracking device including motivational feedback in comparison with activity tracking …

40 - 85 years of age Both Phase N/A
D Department of Physiotherapy and Rehabilitation, Prof

The Effect of Whole-Body Vibration Treatment Before Total Knee Arthroplasty

The study's objective is to investigate the effects of whole-body vibration therapy administered before surgery on various factors related to patients who undergo total knee arthroplasty. These factors include pain, swelling, skin temperature, normal joint movement, knee joint position sense, knee extensor muscle strength, functional status, and patient satisfaction.

55 - 100 years of age Both Phase N/A
R Roland Zügner

Randomised Total Knee Arthroplasty With Attune S+ or NexGen CR

The primary purpose of this study is to evaluate the clinical performance of the Attune S+ knee primarily based on evaluation with use of Oxford Knee Score. The NexGen TKR will be used as reference standard. The second aim is to study component migration with model-based RSA in a subgroup …

40 - 75 years of age Both Phase N/A
W WEI-TENG WENG, bachelor

Continuous Infusion and Intermittent Bolus Adductor Canal Block for Total Knee Arthroplasty

The investigators believed the analgesic efficacy of adductor canal block on patients receiving total knee arthroplasty. However, the analgesic effects of different delivery regimens and duration of effects are variable. The investigators hypothesize that using continuous infusion and shorter interval bolus of local anesthetics to perform adductor canal block will …

20 - 100 years of age Both Phase N/A

Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty

Single-arm, single-center, no sham or placebo, prospective pilot trial designed to evaluate the safety and efficacy of transcatheter arterial embolization in patients with persistent knee pain resistant to conservative management for at least 9 months after total knee arthroplasty (TKA). Eligible participants will receive geniculate artery embolization (GAE) using Embozene™ …

30 - 85 years of age Both Phase N/A
B Birgit Donck

Evaluation of Standard and Robot Assisted Total Knee Arthroplasty With a Bicrucatie Retaining Prosthesis

The first study goal is to compare the outcomes between Posterior Stabilized and Bicruciate Retaining TKA. Additionally, the second goal is to evaluate the effect of robot assisted surgery in both Posterior Stabilized and Bicruciate Retaining TKA.

- 80 years of age Both Phase N/A
G Gianluca Perseghin, MD

Persistent Post Surgical Pain After Total Knee Arthroplasty

Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this latter technique may reduce persistent postoperative pain six months after surgery

18 - 85 years of age Both Phase N/A
R Rajavithi

Comparative Effect of Mechanical and Functional Alignment in Bilateral Total Knee Arthroplasty on Ankle Alignment

Mechanical alignment (MA) in total knee arthroplasty (TKA) is the most commonly used with well-documented long-term results, however 20% of patients express dissatisfaction following primary TKA. Alternative alignment philosophies have been proposed, aiming to improve patient clinical outcomes and satisfaction. However, evaluation is focused mainly on knee alignment, the pathological …

20 - 80 years of age Both Phase N/A

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