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A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease

A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease

Recruiting
18-70 years
All
Phase 2
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Overview

The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.

Eligibility

Inclusion Criteria:

  • Established atherosclerotic cardiovascular disease (ASCVD) and/or at a high risk of ASCVD

Exclusion Criteria:

  • History of confirmed or suspected homozygous familial hypercholesterolemia (HoFH)
  • Chronic liver disease
  • Current treatment with PCSK9 inhibitor or prior treatment within specified timeframe

Study details
    Atherosclerosis
    Cardiovascular Disease
    Hypercholesterolemia

NCT07839936

Verve Therapeutics, Inc.

14 November 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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