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Trial Phase: Syndemic Adapted Medly Uganda

Trial Phase: Syndemic Adapted Medly Uganda

Recruiting
18 years and older
All
Phase N/A

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Overview

The purpose of this study is to evaluate the effectiveness of the Syndemic-Adapted Medly Uganda (SAMU) in improving mental health care among adults living with HIV and hypertension in Uganda. In sub-Saharan Africa (SSA), there is a high prevalence of depression and anxiety among people living with HIV (PLHIV) as well as alcohol use disorder (AUD). PLHIV who experience depression are less likely to link to HIV care, adhere to antiretroviral therapy, and achieve viral suppression. Building on research conducted to adapt Medly Uganda for mental health using a syndemic framework, this study aims to assess the effectiveness of SAMU on mental health screening and diagnosis. This will be accomplished through a two-arm trial in which 1. participants will be enrolled, screened, re-screened, and assessed for diagnosis and linkage to care for depression, anxiety and AUD and 2. evaluate the factors impacting sustained engagement in the SAMU program, through mixed methods.

Description

All staff will be trained in mental health screening prior to the trial launch, and all clinics will be equipped with health education materials to raise awareness of mental health, self-care and available resources in the clinic and community

Eligibility

Inclusion Criteria:

  • Patient at a participating HIV clinic site
  • Currently living in Uganda with no intention of moving abroad in next 2 years
  • Access to a mobile phone
  • Basic reading skills in one or more of the offered languages (English, Luganda) as determined by the Research Assistant.

Exclusion Criteria:

  • No access to a mobile phone
  • Inability to provide informed consent based on assessment by the onsite Research Assistant or HCW

Healthcare Workers/Caregivers Criteria:

  • Age \>=18 years
  • Healthcare worker at participating site or caregiver for study participant at site
  • Basic reading skills in one or more of the offered languages (English, Luganda) as determined by the Research Assistant

Study details
    Mental Health

NCT07525271

Yale University

7 November 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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