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Comparing Intravitreal Injection Pain Scores Using Iheezo (Chloroprocaine Hcl Ophthalmic Gel 3%) Versus Subconjunctival Lidocaine (2%): A Randomized, Controlled Trial

Comparing Intravitreal Injection Pain Scores Using Iheezo (Chloroprocaine Hcl Ophthalmic Gel 3%) Versus Subconjunctival Lidocaine (2%): A Randomized, Controlled Trial

Recruiting
18 years and older
All
Phase 4
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Overview

This will be a prospective, randomized, controlled non-inferiority trial comparing the efficacy of Iheezo versus subconjunctival 2% lidocaine in reducing intravitreal injection pain scores up to 24 hours after injection.

Description

The purpose of this study is to assess and compare patient pain and symptom levels up to 24 hours post-intravitreal injection when using Iheezo (Chloroprocaine HCl ophthalmic gel 3%) versus subconjunctival Lidocaine (2%) for pre-procedure anesthesia. Both medications are approved to be used for pre-procedure anesthesia. Approximately 80 subjects will participate in this study.

Eligibility

Inclusion Criteria:

  • At least 1 previous intravitreal injection in the last 180 days from screening.

Exclusion Criteria:

  • History of more than 13 intravitreal injections.

Study details
    No Condition

NCT07895420

Retina Research Institute, LLC

31 October 2026

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