Overview
This study aims to evaluate serum anti-Müllerian hormone (AMH) levels and complementary hormonal parameters, including follicle-stimulating hormone (FSH), estradiol, thyroid-stimulating hormone (TSH), and free thyroxine (fT4), in women with breast cancer and healthy female controls.
The study will generate preliminary real-world data on AMH and related hormonal parameters and assess the feasibility of implementing AMH testing into routine clinical practice.
Description
The study will include women aged 20-55 years. Patients with breast cancer will be enrolled at different stages of their disease and treatment, including newly diagnosed treatment-naive patients, patients who have completed chemotherapy, patients receiving endocrine therapy without prior chemotherapy, and patients undergoing follow-up after treatment.
In patients with breast cancer, hormonal measurements will be obtained as part of routine clinical care, based on the treating physician's decision. No additional study-specific blood sampling or interventions will be performed. Relevant clinical data will be collected from medical records.
Healthy volunteers will undergo a single blood sampling procedure and complete a brief questionnaire covering gynecological history, smoking status, and body mass index (BMI).
The hormonal assessment will include serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, thyroid-stimulating hormone (TSH), and free thyroxine (fT4).
The collected data will be used to describe hormonal profiles in both study populations and assess the feasibility of routine AMH testing in clinical practice. The findings may provide preliminary data for future research on the clinical utility of AMH in women with breast cancer.
Eligibility
Inclusion Criteria:
- Women aged 20-55 years.
- Patients with a diagnosis of breast cancer at any of the specified stages of treatment or follow-up, or healthy female volunteers.
- Blood sampling as part of routine clinical care (breast cancer patients) or willingness to undergo a single blood draw (healthy volunteers).
Exclusion Criteria:
- Inability or unwillingness to participate in the study.
