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Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)

Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)

Recruiting
18-55 years
All
Phase 1

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Overview

The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI. Specifically, the study will: Evaluate PTSD Symptom Reduction - PTSD symptoms, specifically hyperarousal and hypervigilance will be assessed using the Davidson Trauma Scale, which will provide insight into improvements PTSD symptom reduction.

Eligibility

Inclusion criteria:

  • History of one or more concussions.
  • Presence of mild-to-moderate PTSD symptoms, defined as a score between 20 and 44 on the Davidson Trauma Scale (DTS), indicating clinically relevant but not severe symptomatology (Davidson et al., 1997).
  • Prior or ongoing therapy, defined as current or recent (within the last 3 months) engagement in standard care treatments such as psychiatric medication management, and evidence-based psychotherapy targeting mTBI or PTSD symptoms.
  • Prior U.S military service (any duration and any branch) is required for eligibility.

Exclusion criteria:

  • Age over 55 to reduce confounding effects of age-related neurodegeneration and cognitive decline.
  • Diagnosis of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
  • Active substance abuse.
  • Presence of unrelated neurological conditions such as epilepsy, stroke, seizure disorders, or neurodegenerative diseases (e.g., Alzheimer's, Parkinson's).
  • Significant cognitive impairment, assessed by standardized cognitive screening, which would interfere with the ability to participate fully in VR and therapy sessions.
  • Physical impairments that would prevent safe engagement in VR and therapy.

Study details
    Traumatic Brain Injuries
    TBI (Traumatic Brain Injury)
    MTBI - Mild Traumatic Brain Injury
    mTBI
    Traumatic Brain Injury | Patient
    Traumatic Brain Injury and Co-occurring Disorders
    PTSD - Post Traumatic Stress Disorder

NCT07890337

Johns Hopkins University

24 October 2026

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