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Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial

Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial

Recruiting
18-90 years
All
Phase 2
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Overview

Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not. It is hypothesized that a complete full thickness myotomy could lead to higher rates of gastroesophageal reflux disease (GERD). In this study we compare performing a Full-thickness myotomy with a progressive myotomy (proximal half circular only, distal half full-thickness, and assessment the different outcomes including efficacy and the incidence of postprocedural GERD.

Eligibility

Inclusion Criteria:

  • Achalasia confirmed by manometry
  • Type 1 and type 2 Achalasia
  • Eckhart score \>3
  • Fit to undergo anaesthesia

Exclusion Criteria:

  • Type 3 achalasia and other esophageal motility Disorders
  • Hiatus hernia
  • Coagulopathy

Study details
    Achalasia Cardia
    Achalasia

NCT07875686

Cairo University

21 October 2026

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