Overview
This research is studying a supplement called tributyrin in people with Progressive Supranuclear Palsy (PSP) to learn about its safety and tolerability as a potential treatment. The goal of this research study is to see if a similar supplementation regimen and virtual testing is feasible for people with PSP.
Description
This is a sub-study of NCT07154511.
Eligibility
Inclusion Criteria:
- Male or Female, age 45 years and over.
- Diagnosis of PSP-Richardson syndrome (RS) based on Movement Disorder Society (MDS) Criteria, including
- Vertical supranuclear gaze palsy.
- Repeated unprovoked falls OR tendency to fall on the pull test within 3 years.
- Access to the internet and webcam for virtual visits.
- Presence of a caregiver.
Exclusion Criteria:
- Recent history of significant, uncontrolled GI disease such as Gastroesophageal reflux disease, colorectal cancer.
- Significant metabolic or uncontrolled medical comorbidity.
- Regular use of typical anti-cholinergic drugs.
- Women of child-bearing potential, or who are pregnant and/or nursing.
- Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory.
- Any other condition or criterion that, in the opinion of the investigators, would preclude safe and meaningful participation in the study.
