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A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Established Cardiovascular Disease

A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Established Cardiovascular Disease

Recruiting
40 years and older
All
Phase 3
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Overview

This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity and established cardiovascular disease (CVD).

Eligibility

Inclusion Criteria:

  • Participants with BMI ≥ 27 kg/m² and established CVD
  • History of at least one self-reported unsuccessful dietary effort to lose body weight

Exclusion Criteria:

  • Known history of Type 1 diabetes mellitus
  • Current or previous treatment with petrelintide or any other amylin analog

Study details
    Obesity or Overweight
    Cardiovascular Disease

NCT07843472

Hoffmann-La Roche

21 October 2026

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