Overview
The purpose of this study is to determine whether a circadian rhythm exists in anti-FXa levels and AT3 activity in hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis
Eligibility
Inclusion Criteria:
- Inpatient admission for acute traumatic injury ≥72 hours
- Prescribed LMWH subcutaneous for VTE chemoprophylaxis
Exclusion Criteria:
- Pregnancy
- Brain hemorrhage or non-survivable injury
- Chronic Kidney disease ≥ 3b estimated Glomerular Filtration Rate (eGFR) less than 30 interferes with coagulation
- Chronic liver failure
•-Acute stimulant use of cocaine and methamphetamine
- Active VTE or ongoing anticoagulation at admission
- History of coagulopathy or inherited bleeding disorders
- Chronic alcohol as defined as a documented diagnosis of alcohol use disorder or alcohol consumption exceeding established risk thresholds (men \>14 drinks/week; women \>7 drinks/week) within the prior 3-6 months
- Unmanaged psychiatric conditions as defined as diagnosed psychiatric disorder with evidence of inadequate or no active treatment or documented poor symptom control
- Neurologic injury involving hypothalamic or circadian regulatory centers
