Overview
Randomized study comparing the structural efficacy of methotrexate versus placebo in digital osteoarthritis
Eligibility
Inclusion Criteria:
\- Digital osteoarthritis (IPD and IPP) according to ACR criteria (with an X-ray of the hands taken less than 3 months ago, showing at least 3 joints with digital osteoarthritis KL\>=2) and symptomatic for more than three months
Exclusion Criteria:
- Having a bilirubin level \> 5 mg/dl (85.5 µmol/l)
- Pregnant or breastfeeding women (a urine pregnancy test will be performed on women of childbearing age),
- Injection of hyaluronic acid within the previous 6 months,
- Injection of cortisone derivatives within the previous 3 months,
- Presence of psoriasis,
- Inflammatory rheumatism,
- Microcrystalline arthropathy,
- Joint prosthesis in one of the joints of the hand,
- Planned placement of a joint prosthesis in the hand during the study period,
- Major progressive disease (life-threatening cardiovascular disease, hematopoietic cancers including myeloma, cancers with risk of bone metastases),
- Liver failure.
- Severe renal failure (creatinine clearance less than 50 ml/min).
- Positive hepatitis B serology.
- Tuberculosis, hepatitis C, HIV positive, or other immunodeficiency syndromes.
- Uncontrolled infections.
- Use of corticosteroids.
- Use of morphine derivatives,
- Taking Bactrim,
- Taking high doses of aspirin (greater than or equal to 500mg/day),
- Contraindications to the use of methotrexate,
