Overview
The goal of this clinical trial is to measure hand grip strength in adults with pancreatic ductal adenocarcinoma (PDAC). The main questions it aims to answer are:
- Is it feasible to measure hand grip strength as part of a clinic visit?
- Are changes in hand grip strength related to changes in body composition?
- Is hand grip strength related to a person's well-being?
- Is hand grip strength related to how a tumour responds to treatment?
Participants will squeeze a device with their hand to measure their hand grip strength and complete questionnaires about their well-being when they are seen in clinic for their regular medical care for PDAC.
Eligibility
Inclusion Criteria:
- Age 18 years or older.
- Histological and/or radiological diagnosis of resectable, non-resectable, or metastatic PDAC. For resectable PDAC, adjuvant setting only.
- ECOG performance status 0-2.
- Life expectancy greater than 6 months as judged by the investigator.
- Planned for treatment, either as part of routine care or in combination with an investigational agent within another study.
- Ability to hold a dynamometer with one hand.
Exclusion Criteria:
- Individuals with CT imaging performed outside of Vancouver, BC, Canada.
- Individuals who are unfit to undergo CT imaging of the third lumbar vertebra (L3).
- Individuals who are currently participating in a structured moderate intensity resistance training program.
- Individuals who are otherwise judged by the investigator to be unfit to proceed with this protocol.
- Unable to comply with study assessments and follow-up.
