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Patient Navigation for HER2+ Metastatic Breast Cancer Patients Treated With Tucatinib

Patient Navigation for HER2+ Metastatic Breast Cancer Patients Treated With Tucatinib

Recruiting
18 years and older
Female
Phase N/A

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Overview

The goal of this study is to test a novel nurse-delivered patient navigation program for women with HER2+ metastatic breast cancer (mBC) receiving tucatinib, trastuzumab, and capecitabine. The program will focus on enhancing understanding of the treatment regimen, managing symptoms and adherence, and improving coping and self-management skills. If successful, the program could be integrated into clinical care to better support mBC patients. The main question the study aims to answer is: is the patient navigation program feasible and acceptable for mBC patients?

Participants will receive patient navigation sessions over about 6 weeks. Participants will also complete study assessments via electronic survey at baseline and at about 3 and 6 weeks after enrollment, with the last assessment occurring after completion of the patient navigation program sessions. Participants will also complete a post-program exit interview.

Eligibility

Inclusion Criteria:

  • female (sex assigned at birth);
  • ≥18 years of age at enrollment;
  • diagnosed with HER2+ metastatic breast cancer (mBC);
  • receiving treatment with tucatinib combined with capecitabine and trastuzumab;
  • able to speak and read English

Exclusion Criteria:

  • visual or hearing impairment;
  • severe cognitive impairment;
  • severe mental illness interfering with ability to participate

Study details
    HER2+ Metastatic Breast Cancer (MBC)

NCT06983691

Duke University

12 September 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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