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Effect of Local Anesthetic Concentration on Rebound Pain

Effect of Local Anesthetic Concentration on Rebound Pain

Recruiting
18 years and older
All
Phase 4

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Overview

Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.

Eligibility

Inclusion Criteria:

  • Total shoulder replacement patients (anatomic and reverse)
  • Adult patients (greater than or equal to 18 years)
  • Any gender
  • Any race

Exclusion Criteria:

  • \- Chronic Pain diagnoses including:
  • substance/opioid use disorder
  • complex regional pain syndromes
  • fibromyalgia
  • Daily persistent opioid use spanning 3 months prior to surgery date
  • Allergy to local anesthetics or NSAIDS
  • Respiratory pathologies including:
  • CPAP- non-compliant / untreated obstructive sleep apnea
  • COPD
  • Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc)
  • Contralateral diaphragm dysfunction
  • BMI \> 40
  • Ipsilateral extremity pre-existing nerve injury
  • GFR \< 60
  • NSAID contraindications
  • Inability to follow up
  • Revision surgery
  • Patients requesting block as primary (avoidance of general anesthesia)
  • Need or request for brachial plexus catheter or liposomal bupivacaine
  • Vulnerable populations (pregnancy, incarceration, etc)
  • non-English speaking

Study details
    Rebound Pain
    Shoulder Arthroplasty
    Interscalene Block

NCT07146685

University of Virginia

12 September 2026

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