Overview
With this study, the investigators want to investigate how deep brain stimulation (DBS) affects various cognitive and psychiatric symptoms of Parkinson's disease (PD). In particular, they will examine whether stimulation of the left hemisphere has a different effect than stimulation of the right hemisphere on cognitive and psychiatric symptoms.
Description
Previous studies have shown that motor symptoms improve with DBS in PD. It is also know that DBS can have an effect on cognitive and psychiatric symptoms. However, in the studies completed so far, it has not yet been possible to conclusively assess the exact effect of the stimulation itself on various cognitive and psychiatric symptoms. In particular, there is currently no data on how the precise localization of stimulation at the target site-the subthalamic nucleus (STN)-affects cognitive and psychiatric symptoms. It is not yet clear whether electrical stimulation of the right subthalamic nucleus has different effects on cognition and mood than stimulation of the left subthalamic nucleus. The aim of this study is to investigate whether DBS of the left hemisphere affects cognition and mood differently than DBS of the right hemisphere.
Eligibility
Inclusion Criteria:
- Diagnosed with Parkinson's disease
- Treated with subthalamic nucleus deep brain stimulation (STN-DBS)
- For part I: General research consent for the analysis of routine clinical data
- For part II of the study: ability to provide informed consent
- native German or French speaker
- Montreal Cognitive Assessment with score ≥ 20
Exclusion Criteria:
- Atypical Parkinsonism
- Other disease affecting the brain (e.g. Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, non-provoked epilepsy, brain tumour, etc.)
- Haemorrhage during implantation of STN-DBS, which resulted in permanent cognitive or physical impairment
- Schizophrenia, ongoing substance abuse, bipolar disorder or autism
- For part II: Severe depressive disorder and/or suicidality
- Insufficient quality or lack of brain imaging data pre and/or post STN-DBS
