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Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Recruiting
40 years and older
All
Phase N/A

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Overview

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

  1. Be randomly divided into getting their steroid injection on the inside or outside of their knee.
  2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Eligibility

Inclusion Criteria:

  • Age ≥ 40
  • Clinical diagnosis of knee OA with predominant medial compartment symptoms
  • Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
  • Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
  • Able to provide informed consent
  • Able to complete phone, email, or MyChart follow-ups in English

Exclusion Criteria:

  • Predominant lateral compartment OA or patellofemoral-only OA
  • Inflammatory arthritis (RA, gout flare, etc.)
  • Suspected or confirmed joint infection or overlying cellulitis
  • Prior knee arthroplasty on the index knee
  • Planned surgery for index knee within 12-week follow-up
  • Inability to complete follow-up assessments
  • Other clinician-determined contraindication to CSI

Study details
    Osteoarthitis
    Osteoarthritic Knee Pain
    Osteoarthritis (OA)
    Osteoarthritis (OA) of the Knee
    Osteoarthritis in the Knee

NCT07804446

University of Chicago

5 September 2026

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