Overview
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:
- Be randomly divided into getting their steroid injection on the inside or outside of their knee.
- Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Eligibility
Inclusion Criteria:
- Age ≥ 40
- Clinical diagnosis of knee OA with predominant medial compartment symptoms
- Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
- Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
- Able to provide informed consent
- Able to complete phone, email, or MyChart follow-ups in English
Exclusion Criteria:
- Predominant lateral compartment OA or patellofemoral-only OA
- Inflammatory arthritis (RA, gout flare, etc.)
- Suspected or confirmed joint infection or overlying cellulitis
- Prior knee arthroplasty on the index knee
- Planned surgery for index knee within 12-week follow-up
- Inability to complete follow-up assessments
- Other clinician-determined contraindication to CSI


