Overview
This multicenter retrospective cohort study aims to evaluate the prognostic value of functional liver volume and total liver volume in patients with unresectable hepatocellular carcinoma (HCC) undergoing immunotherapy. The study explores whether baseline liver volume metrics can effectively predict survival outcomes and treatment responses in this patient population to assist in clinical decision-making.
Description
This study retrospectively analyzes the clinical, laboratory, and imaging data of patients with unresectable hepatocellular carcinoma (HCC) who received immunotherapy across multiple clinical centers. Pre-treatment imaging data will be utilized to segment and quantify functional liver volume and total liver volume. Statistical and survival analyses will be performed to evaluate the correlation between these volumetric metrics and patient prognosis, including overall survival and progression-free survival, aiming to establish a robust stratification approach for individualized treatment strategies.
Eligibility
Inclusion Criteria:
- Age \>= 18 years.
- Clinically or histologically confirmed unresectable hepatocellular carcinoma (HCC).
- Received immunotherapy as part of their tumor treatment regimen.
- Availability of high-quality baseline pre-treatment imaging data suitable for functional liver volume and total liver volume segmentation.
- Complete clinical and follow-up survival data.
Exclusion Criteria:
- \- Prior surgical resection or liver transplantation for HCC.
- Co-existence of other concurrent primary malignant tumor types.
- Severe image artifacts or technical limitations that prevent robust liver volume quantification.
- Incomplete medical records, missing key baseline clinical data, or loss to follow-up.
