Overview
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections.
The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.
Eligibility
Inclusion Criteria:
Age \>18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.
Exclusion Criteria:
- Age \<18 years old
- Pregnant women
- Infected patients
- Known cefazolin allergy
- Other molecule used for the antibiotic prophylaxis
- Guardianship or conservatorship
- Patients under curative antibiotherapy
- Non sterile pre operative CSF
- Refusal to participate
