Overview
This study aims to evaluate the clinical and radiographic effects of 0.2% Thymoquinone gel on bone density, bone width, and socket preservation after tooth extraction.
Description
Tooth extraction triggers a cascade of biological events which lead to significant remodeling of the alveolar ridge, frequently resulting in reductions in both bone width and height.
The concept of alveolar ridge preservation (ARP) has developed to address the bone resorption that follows extraction. ARP aims to maintain ridge dimensions and reduce the need for further augmentation before implant placement.
Among these, the small-molecule Thymoquinone (TQ), derived from Nigella sativa, has demonstrated significant osteogenic, anti-inflammatory, and antioxidant effects in preclinical studies.
Eligibility
Inclusion Criteria:
- Age: 18-50 years.
- Both sexes.
- Patients requiring extraction of upper posterior teeth will be recruited.
Exclusion Criteria:
- Healthy subjects with intact sockets after extraction.
- Normal mouth opening and good oral hygiene.
- No systemic conditions affecting bone healing.
