Overview
To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.
Description
This study will enroll 50 patients with ST-segment elevation myocardial infarction (STEMI). Peripheral blood will be collected from these patients for immune cell subset analysis, serum cytokine evaluation, and neutrophil sorting for transcriptome sequencing. At 1 week after admission, cardiac magnetic resonance (CMR) will be performed to evaluate the myocardial salvage index, area of late gadolinium enhancement (LGE), microvascular obstruction (MVO), extracellular volume (ECV), and left ventricular ejection fraction (LVEF).
Eligibility
Inclusion Criteria:
\---- Age \> 18 and ≤ 80 years old
\- Patients with acute STEMI within 12 hours of symptom onset who are planned to receive PPCI
Exclusion Criteria:
- Prior revascularization
- Known allergy to gadopentetate dimeglumine contrast agent
- Pregnancy or planned pregnancy within the next 6 months
- Life expectancy \< 1 year
- Metallic implants or claustrophobia that precluded MRI
- Severe COPD or inability to hold breath for MRI
- Severe hepatic or renal dysfunction (ALT \> 5×ULN or eGFR \< 15 mL/min/1.73 m²)
