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Adapted Cardiopulmonary Resuscitation Study

Adapted Cardiopulmonary Resuscitation Study

Recruiting
18 years and older
All
Phase N/A

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Overview

The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment.

Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference .

Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols.

The intervention group will receive a modified treatment including:

  • thorax compression via mechanical device (LUCAS 3)
  • head up Cardiopulmonary Resuscitation (cpr)
  • use of an impendance threshold device (ITD) module
  • arterial line placement
  • continuous epinephrin infusion via infusion pump
  • double sequence defibrillation

Eligibility

Inclusion Criteria:

  • Age\> 18 years
  • time of resuscitation \<21 minutes when enrollement starts

Exclusion Criteria:

  • obvious pregnancy
  • contraindications for the use of Lucas 3
  • time of resuscitation \>21 minutes and etCO2 \<15 mmHg upon arrival of the emergency physician on scene
  • Exclusion from the emergency physician from study due to futility.

Study details
    Cardiac Arrest (CA)

NCT07754656

Johannes Kepler University of Linz

15 August 2026

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