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Managing Depressive Symptoms in ADPKD

Managing Depressive Symptoms in ADPKD

Recruiting
18-70 years
All
Phase N/A
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Overview

The purpose of this research is to evaluate the feasibility and effectiveness of Digital Neurotherapy (DNT) or Capacity Coaching (CC) for managing symptoms of depression and self reported pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to education alone.

Eligibility

Inclusion criteria:

  • Confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria
  • Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR \>10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months)
  • Clinical or self-diagnosis of depression
  • English-language fluency

Exclusion criteria:

  • Suicidal ideation/unstable mental illness of any kind
  • Lack of access/ability to use internet-based programs
  • eGFR \<10 ml/min/1.73m2
  • Anticipated dialysis or transplant within 6 months
  • Prior chronic dialysis
  • Prior organ (liver or kidney) transplant
  • Lack of English language fluency
  • Significant cognitive impairment (Mini Mental Status Exam (MMSE))

Study details
    Autosomal Dominant Polycystic Kidney Disease

NCT07745920

Mayo Clinic

8 August 2026

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