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Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:

Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:

Recruiting
18 years and older
All
Phase N/A

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Overview

Chronic opioid users undergoing surgery are at increased risk of CPSP, contributing to long-term disability, decreased quality of life, and prolonged opioid exposure. Existing preventive strategies remain limited, and early postoperative monitoring may represent a key opportunity for intervention. Evidence suggests that transitional pain services can improve outcomes by optimizing pain control and reducing long-term opioid consumption, but implementation is heterogeneous and often resource-intensive. Telemedicine offers a scalable alternative, enabling early specialized evaluation and timely therapeutic adjustments while maintaining accessibility. This randomized controlled trial will compare standard postoperative follow-up with standard follow-up plus a specialized teleconsultation performed between postoperative day 15 and 28. The intervention aims to detect insufficiently controlled pain, signs of neuropathic pain, or maladaptive opioid use, and to propose individualized therapeutic adjustments when required.

Participants will be followed for 6 months. Primary assessment will occur at 3 months to determine CPSP incidence. Secondary assessments will include pain trajectory (intensity, neuropathic features, functional interference), opioid consumption and misuse, quality of life, and a descriptive medico- economic evaluation

Eligibility

Inclusion Criteria:

  • Age ≥18 years
  • Elective non-urgent surgery with expected moderate or higher postoperative pain
  • Chronic preoperative opioid use
  • Written informed consent
  • affiliated with a national social security scheme

Exclusion Criteria:

  • Ambulatory surgery
  • Endoscopic or palliative surgery
  • Patients receiving opioid substitution therapy
  • Non-medical opioid use
  • Intrathecal/epidural analgesia or implanted neurostimulator
  • Legally protected adults
  • Severe psychiatric or neurodegenerative disorders

Study details
    Chronic Postsurgical Pain
    Chronic Opioid Users
    Transitional Pain Service
    Postoperative Pain
    Perioperative Medicine

NCT07717151

Centre Hospitalier Universitaire, Amiens

25 July 2026

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