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A Positron Emission Tomography Study to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants

A Positron Emission Tomography Study to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants

Recruiting
18-55 years
All
Phase 1

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Overview

The purpose of this study is to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants

Eligibility

Inclusion Criteria:

  • Participants must be healthy male and female (as assigned at birth) who are individuals not of childbearing potential (INOCBP) without clinically significant deviation from normal in medical history, PE, 12-lead ECG, and clinical laboratory assessments.
  • Participants must have a BMI of 18 to 30 kg/m\^2, inclusive, and total body weight ≥ 50 kg.

Exclusion Criteria:

  • Participants must not have presence or history of any clinically relevant abnormality, condition, or disease-CNS, cardiovascular, renal, hepatic, hematologic, GI, endocrine, pulmonary, psychiatric, neurologic (eg, seizure disorder), or immunologic.
  • Participants must not have history of rhabdomyolysis.
  • Participants must not have current or recent (within 3 months of study intervention administration) clinically significant GI disease.
  • Other protocol defined inclusion/exclusion criteria apply.

Study details
    Healthy Volunteers

NCT07655518

Bristol-Myers Squibb

11 July 2026

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