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Effect of Systemic Vitamin D on Dental Implant Osseointegration

Effect of Systemic Vitamin D on Dental Implant Osseointegration

Recruiting
20-60 years
All
Phase N/A

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Overview

The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.

Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.

Description

Implant success depends on several factors surgical and prosthetic factors (surgical technique and operator experience, timing and type of prosthetic loading and quality of pros-thetic rehabilitation), implant-related factors (material, design and surface), and patient-related factors (bone volume/quality at the recipient site and host response.

Despite the high success rate of dental implants, which is reported to be around 95%, failures due to lack of osseointegration remain a significant challenge Implant failures are classified according to the timing of the loss to Early Dental Implant Failure (EDIF) or late dental implant failure (LDIF). Early implant failure occurs due to improper implant placement and restoration, low bone volume or density, systemic conditions, or smoking.

Recent research has indicated that systemic health factors, particularly nutritional status, can significantly influence the process of osseointegration. Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone.

Vitamin D also exerts direct actions on bone (probably by regulating the expression of several bone growth factors). It controls mineral metabolism and the bone homeostasis by increasing calcium availability, by regulating PTH secretion, and by direct effects on bone formation and resorption.

Eligibility

Inclusion Criteria:

  • Adults aged 20-60 with diagnosed vitamin D deficiency (\<20 ng/mL).
  • Edentulous area in the posterior mandible or maxilla.
  • No history of previous dental implant failure, metabolic bone diseases, or conditions affecting bone healing.
  • Both genders are included

Exclusion Criteria:

  • Severe systemic diseases that could interfere with healing.
  • Patients already on vitamin D or calcium supplements.
  • Smokers or patients with poor oral hygiene practices.
  • Pregnant females

Study details
    Dental Implant
    Dental Implant Failed
    Vitamin D Deficiency

NCT07684404

Future University in Egypt

11 July 2026

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