Overview
The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.
Description
Patients with ANCA vasculitis with rapidly progressive glomerulonephritis with "crescent" will be compared to six other groups made up of patients with another nephropathy 1/extramembranous glomerulonephritis and 2/ nephropathy with minimal glomerular lesion (LGM) characterized by the absence of significant tubulointerstitial fibrosis lesions and slow evolution towards end-stage chronic renal failure ). Other groups of patients will 3/have interstitial nephropathy, 4/IgA mesangial glomerulopathy , 5/diabetic nephropathy, or 6/collapsing focal segmental hyalinosis.
Eligibility
Inclusion Criteria:
- Patients with an indication for initial diagnostic PBR on native kidney
- 18 ans ≥ Age ≤ 90 ans
- Affiliation to french health insurance
- Patient having given consent
For the ANCA vasculitis group:
• Diagnosis of ANCA vasculitis retained on renal biopsy with ANCA anti-proteinase 3 (PR3) or ANCA anti-myeloperoxidase (MPO)
For the control groups:
• Diagnosis retained after the renal biopsy
- Interstitial Nephritis
- Or glomerular nephropathy such as minimal change nephropathy
- Or Segmental hyalinosis in itscollapsing form
- Or Extramembranous Glomerulopathy,
- Or glomerulopathy with mesangial IgA deposits
- Or diabetic nephropathy.
Exclusion Criteria:
- Kidney transplant patient
- Patient on dialysis (hemodialysis or peritoneal dialysis)
- Patient under legal protection, guardianship or curatorship
- Pregnancy or breastfeeding
- Enrollement in an interventional study except studies relating to ANCA vasculitis and nephropathy with mesangial IgA deposits.
