Overview

Researchers are looking for new ways to treat certain types of advanced and/or metastatic solid tumors.

The main goal of this study is to learn about the safety of different doses of MK-4884 and if participants tolerate them.

Eligibility

Inclusion Criteria:

• Has a histologically or cytologically confirmed diagnosis of 1 of the following unresectable (locally advanced) and/or advanced (metastatic) solid tumors:
• Colorectal carcinoma (CRC)
• Renal cell carcinoma (RCC) that contains a clear cell component (with or without sarcomatoid and/or rhabdoid features)
• Nonsquamous non-small cell lung cancer (NSCLC)
• Biliary tract cancer (BTC) (intra-or extrahepatic cholangiocarcinoma (CCA)) or gallbladder cancer (GBC)
• Has measurable disease by Response Evaluation Criteria In Solid Tumors 1.1 (RECIST 1.1)
• Has adequate organ function
• Participants with human immunodeficiency virus (HIV) infection must have well controlled HIV on stable antiretroviral therapy (ART) for at least 4 weeks
• Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received Hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load
• Participants with a history of Hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable

Exclusion Criteria:

• Has gastrointestinal malabsorption, a surgical procedure or a condition that could affect the absorption of the study drug
• Has a history of clinically significant cardiac, cardiovascular and/or cerebrovascular disease
• Has a serious nonhealing wound, ulcer, or bone fracture
• Has an active infection(s) requiring systemic therapy
• HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
• Known additional malignancy that is progressing or has required active treatment within the past 2 years
• Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis
• Has a history of stem cell/solid organ transplant
• Has not adequately recovered from major surgery