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Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

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Overview

The goal of this observational study is to improve the detection of dementia with Lewy bodies (DLB) and its prodromal phases, as well as advancing our current understanding of biological mechanisms and therapeutic options. The data is acquired at cognitive clinics in Stockholm (Sweden) and combined with national and international data to increase statistical power, representativeness and replication of results. Participants undergo collection of clinical assessments, neuroimaging and fluid biomarkers.

Description

The cohort from cognitive clinics in Stockholm (Sweden) constitutes the Find-DLB cohort, and comprises patients included retrospectively up to 2020 and prospectively from 2020 onward.

Eligibility

Inclusion Criteria:

  • At least one core clinical feature of dementia with Lewy bodies such as visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behaviour disorder.

Exclusion Criteria:

  • Causes of cognitive impairment other than those related to dementia or MCI. Current or pass drug use.

Study details
    Dementia With Lewy Bodies (DLB)
    Mild Cognitive Impairment (MCI)
    Cognitively Unimpaired
    Other Dementias

NCT07629349

Karolinska Institutet

27 June 2026

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