Overview
This CML disease registry (ASC4REAL-2) aims to gather evidence on the tolerability, safety, effectiveness, and patient-reported outcomes (PRO) in real-world healthcare from patients with Ph+-CML-CP treated with TKIs approved for 1L and 2L, including prospective follow-up for 5 years identifying and describing long-term treatment outcomes.
Eligibility
Inclusion Criteria:
- 18 years or older at the time of Ph+-CML-CP diagnosis.
- Receiving TKI treatment (asciminib, bosutinib, dasatinib, imatinib, or nilotinib) in routine medical care either as initial therapy or after 1 prior TKI therapy.
- Receiving treatment at US and US territories (i.e., Puerto Rico) medical practice (e.g. community-based, office-based, hospital-based, academic).
- Signed informed consent form (ICF) prior to participation in the study including agreement to be tokenized so that the patient's anonymized RWD (EMRs and/or claims data) can be accessed.
Exclusion Criteria:
- Active participation in an interventional trial that may influence the management of their Ph+-CML-CP disease.
- Currently being treated with a CML TKI in 3L or beyond.
- Known presence of T315I mutation.
- Currently in TFR phase and are not on active CML TKI therapy.
- Previously received treatment with a prior stem cell transplant
- Pregnant or nursing (lactating) female.
