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Genetic, Microbiological and Behavioral Factors in Obesity

Genetic, Microbiological and Behavioral Factors in Obesity

Recruiting
18-60 years
All
Phase N/A
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Overview

This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1/GIP RA in the treatment of obesity.

200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.

Eligibility

Inclusion criteria

  • Age 18-60 years
  • Consent to participate in the study and providing informed written consent
  • Overweight or obese with a BMI \>27

Exclusion criteria

  • Contraindications to tirzepatide use:
  • Type 1 or type 2 diabetes
  • Pregnancy or breastfeeding
  • Cancer
  • Heart failure
  • Expected lack of patient compliance
  • Taking immunosuppressive medications, steroids, NSAIDs, antibiotics (within 2 weeks prior to sample collection),
  • Autoimmune and inflammatory diseases, acute infectious diseases, AIDS, tuberculosis
  • Mental illness
  • Alcohol dependence syndrome
  • Liver cirrhosis
  • Post-myocardial infarction or stroke

Study details
    Obesity & Overweight
    Obesity
    Genetics

NCT07650149

Jan Kochanowski University

27 June 2026

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