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Optimization of Cardiac Imaging in Women With Early-Stage Breast Cancer

Optimization of Cardiac Imaging in Women With Early-Stage Breast Cancer

Recruiting
18-79 years
Female
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

The purpose of this study is to determine whether a personalized, risk-stratified surveillance strategy can safely reduce unnecessary cardiac imaging while preserving early detection of treatment-related cardiotoxicity in women with breast cancer (BC) receiving HER2-targeted therapy (HER2-TT).

Eligibility

Inclusion Criteria:

  • Female sex, age 18-79 years.
  • Histologically confirmed HER2-positive BC scheduled for ≈12 months of adjuvant HER2-TT
  • Baseline LVEF ≥ 55 % by 2-D echocardiography.
  • Ability to provide informed consent.

Exclusion Criteria:

  • Prior HF, myocardial infarction, or cardiomyopathy.
  • Atrial fibrillation or significant valvular heart disease.
  • Cumulative anthracycline dose ≥ 250 mg/m².
  • Pregnancy or lactation.
  • Inability to comply with study procedures.

Study details
    Breast Cancer With Low to Intermediate HER2 Expression

NCT07630402

University of Rochester

27 June 2026

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