Overview
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Description
Primary Objectives
• To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care
Secondary Objectives
- To determine changes in health-related quality of life changes following ultrasound-guided nsPFA
- To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA.
- To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.
Eligibility
Eligibility Criteria
- Scheduled to undergo ultrasound guided nsPFA as standard of care
- Age 18 to 80 years.
- Capable of providing independent consent.
- Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:
- Benign FNA X 2 or
- Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
- Benign FNA X 1 and radiographic/laboratory evidence of functional nature
- Nodule measuring \>2cm in greatest dimension
- Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
- No abnormal cervical lymph nodes during screening visit .
Exclusion Criteria
- Age \<18
- Patients considered unsuitable for nsPFA by the treating physician
