Overview
To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.
Description
Given the high incidence of postoperative surgical site infections (SSI) potentially attributable to bacterial antimicrobial resistance, the use of beta-lactam/beta-lactamase inhibitor combinations for prophylaxis may reduce SSI rates following hepatobiliary surgery in the current era of high antimicrobial resistance. To test this hypothesis, we propose a prospective pragmatic trial comparing piperacillin-tazobactam with the standard prophylactic regimen of cefuroxime for perioperative infection prevention in patients undergoing hepatobiliary surgery.
Eligibility
Inclusion Criteria:
- Adult patients aged ≥18 years;
- Deemed eligible for elective hepatobiliary surgery;
- Demonstrated comprehension of the study nature and expressed willingness to comply with trial procedures;
- Capable of providing written informed consent.
Exclusion Criteria:
- History of β-lactam allergy or hypersensitivity
- Uncontrolled preoperative infection;
- Current or recent (within the preceding month) systemic corticosteroid administration;
- Severe hepatic or renal impairment;
- Pregnancy or lactation;
- Concurrent enrolment in another clinical trial;
- Any other condition deemed by the investigator to render the patient unsuitable for study participation.
