Overview
The main goal of the project is to assess pain levels and patient comfort during the administration of a 50:50 Nitrous Oxide/Oxygen gas mixture, in comparison to the same parameters under the standard method used at our institution, which includes injecting a local anaesthetic at the site of planned puncture for central venous catheterisation.
Eligibility
Inclusion Criteria:
- Subjects who have not previously received Nitrous Oxide.
- Subjects of both sexes, aged between 18 and 65 inclusive.
- Subjects who have signed informed consent with full disclosure; no study-related procedure may begin until the subject signs the consent form.
Exclusion Criteria:
- Infection at the planned puncture site.
- Pregnancy.
- Intracranial hypertension.
- Vitamin B12 deficiency.
- Hemodynamic instability.
- BMI over 35.
- Glasgow Coma Scale (GCS) score less than 15.
- Presence of chronic pain.
- Neurological disorders.
- Hematologic disorders.
- More than two attempts at venous puncture (Subject Withdrawal Criterion).
- Subject experienced an adverse event requiring early discontinuation (Subject Withdrawal Criterion).
- Withdrawal of consent by the subject (Subject Withdrawal Criterion)
